PROGESTERONE

Progesterone is a vital hormone produced by the ovaries, adrenal glands, and the placenta during pregnancy. It prepares the uterus for pregnancy, supports the uterine lining, prevents early contractions, and contributes to breast development.

While commonly associated with female health, progesterone is also present in males in smaller amounts.

The test offers insights into ovulation, pregnancy health, and hormonal balance, and is used in fertility assessments and identifying causes of irregular bleeding.

This test measures the concentration of progesterone hormone in your bloodstream. Levels fluctuate with the menstrual cycle and pregnancy stage. Accurate interpretation depends on knowing the cycle day or gestation week.

Timing is key. The test is typically taken:

• Around day 21 of a 28-day cycle to confirm ovulation
• During fertility evaluations
• In early pregnancy to assess risk of miscarriage
• To monitor high-risk pregnancies
• When evaluating abnormal bleeding
• To monitor progesterone therapy effectiveness

Risks

• Minor pain or bruising at the needle site
• Rare fainting or infection

Limitations

• Only reflects hormone level at the test moment
• Must be timed accurately within the cycle
• Can vary between individuals and cycles
• Affected by hormone medications

Progesterone (P4) concentration: Typically reported in ng/mL or nmol/L

The report will include your result and reference range for interpretation.

You may need this test if you:

• Are trying to conceive
• Are undergoing fertility treatment
• Are pregnant with symptoms like spotting
• Have irregular periods or bleeding
• Are on progesterone therapy
• Are being evaluated for adrenal or luteal phase issues

• Confirms ovulation
• Assesses luteal phase adequacy
• Helps diagnose fertility issues
• Monitors early pregnancy health
• Guides fertility or hormone treatment
• Offers reassurance through data

• Anovulation
• Luteal phase defect
• Miscarriage or ectopic pregnancy risk
• Ovarian cysts or tumours
• Congenital adrenal hyperplasia (as part of a panel)

• Fasting is usually not required
• Timing based on your cycle is essential
• Doctor’s prescription may be needed
• Inform staff about medications and last period date

Test Procedure

• Blood draw from arm by trained phlebotomist
• Clean site, draw sample, apply bandage

Caution Before the Test

Inform your doctor and technician if:

• You take hormone treatments or supplements
• You are on birth control
• You have a bleeding disorder or faint easily
• You know your last menstrual period or pregnancy week